Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
Indexed in
Publisher
MDPI AG
Contribution Type
text::journal::journal article
Revista
Catalysts
ISSN
2073-4344
Volume
9
Issue
4
Fecha de Publicación
2019-04-01
Autor(es)
Resumen
Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.